For the last three decades, my lab has contributed to the understanding of the following

• Discovery of XTR region of Yp11.2 and Xq21.3, a new recombination region as new Pseudoautosomal Region 3.
• Identification of maternal grandmother age as a risk factor in more young mothers producing Down Syndrome in India.
• Identification of five new genes of dyslexia involved in dendritic spinal-plasticity through whole genome-wide copy-number scan.
• Identification of genomic variants in high-risk genes for congenital heart disease (CHD), autism spectrum disorders (ASD), cardiovascular disease and multiple myeloma through exome sequencing.
• Establishment of global copy number variation (CNV) map using a Genome-wide scan of CNVs in humans across 12 populations and established the burden of the same on coding genome and on miRNA regulation leading to phenotypic diversity.
• Understanding the genomic variations proposing the new human migratory routes with two settlements through CNV studies. CNV studies in human identify the genomic variations which propose new migratory routes with two settlements.
• Establishment of CNVs as markers to identify the genomic variations in Dyslexia, Asthma, CHD, Type 2 Diabetes Mellitus and Parkinson’s disease.
• Genetic study of congenital heart disease which has revealed consanguineous marriages, chromosomal anomalies, and SNPs in GATA4, NKX2.5, and CRELD1 as risk factors.
• Genetic analysis of asthma revealed parental consanguineous marriage and serum ICAM-1 association with asthma, novel SNPs associated and role of ADAM33 interactive pathway in Asthma.
• Identification of differentially expressed genes in Parkinson’s disease; and DNA sequencing-based drug resistance detection for Tuberculosis.
• Work on human genotypic variation in Olfactory Receptor (OR) provides pieces of evidence for the complexity to the continuously occurring OR CNVs.
• Long range interracial hybridization experiments in Drosophila nasuta system have evolved many new stabilized cytoraces in 30 years which would take millions of years in nature that will provide evidence for “adaptive evolution of genome” due to “recombinational speciation” illustrating the power of evolution.
• Whole-genome and transcriptome sequencing of laboratory-evolved cytoraces revealed the introgression and the adaptive evolution of genome in Drosophila .
• Focused on Mating behavior and mating signaling modalities in Drosophila nasuta and the role of Darwinian natural selection acting on key genes involved in speciation and adaptation.
• Induced and isolated second chromosome specific Indirect Flight Muscle mutants in Drosophila melanogaster which are involved in myoblast proliferation, myofibril-assembly, and function.
• Professor (Retd) & DAE- Raja Ramanna Chair -Department of Studies in Genetics and Genomics
• Professor (Honorary) - Sri Sathya Sai University for Human Excellence, Kalaburagi- 2021 to till date.
• Adjunct Professor- Asia Pacific institute of Embryology, Mysuru
• Adjunct Faculty for Biotechnology , Department of Bioscience, Mangalore University, Mangaluru – 2023 to till date
• Chairman - Human Ethical Committee, Mysore Medical College and Research Institute- 2016 to till date
• Consultant - Human Genetics Unit, All India Institute of Speech and Hearing, Mysuru- 2020 to till date
• Fellow of Indian Academy of Sciences (FASc.)- 2017
• Honorary Fellow of Karnataka Science and Technology Academy (FKSTA)- 2020
• Fellow of Indian Academy of Biomedical Sciences (FIABS)- 2023
• Former UGC-BSR Faculty Fellow (2020-2023) &  Former founder Chairman-  Department of Studies in Genetics and Genomics –(2015 to 2020), University of Mysore, Manasagangotri, Mysore-570006

Currently,

• Working on genomic variations of genes involved in Autism Spectrum Disorders and Congenital Heart Diseases to establish gene panels by identifying the more specific potential genes with pathogenic/common variants.